Deflazacort

nature
Acetone-hexane crystallization, melting point 255-256.5℃. [α]D+62.3°(C=0.5, chloroform). UV maximum absorption (methanol) : 241 ~ 242nm(E1cm1%352.5). Acute toxicity LD50 mice (mg/kg) : 5200 orally; 1610 subcutaneous injection. Acute toxicity LD50 rats (mg/kg) : 109 by subcutaneous injection. Acute toxicity LD50 dog (mg/kg) : > 4000 orally; 50 subcutaneous injection.

Third generation glucocorticoids. It has the effects of anti-inflammatory, anti-allergy and increasing glycoconeogenesis. For primary and secondary adrenocortical hypofunction, rheumatism, collagen diseases, skin diseases, allergic diseases, eye diseases, fulminant and disseminated tuberculosis, hematopoietic system disorders, ulcerative colitis, idiopathic nephrotic syndrome, hematopoietic system malignant tumors, etc.

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