(R)-(-) -3-chloro-1,2-propanediol is an organic compound with the chemical name (R)-3-chloro-1,2-propanediol. It is a colorless liquid with a distinctive pungent odor. The compound is slightly soluble in water at room temperature and soluble in many organic solvents such as alcohols, ethers and esters.
Pharmaceutical Intermediate: It serves as a key intermediate in the synthesis of various pharmaceuticals, including L-Carnitine, which is an amino acid that plays a crucial role in metabolism and is used for its potential health benefits in humans .
Chiral Synthesis: Due to its chiral center, (R)-3-chloro-1,2-propanediol is an important building block in the synthesis of other chiral compounds, which are essential in the production of many drugs that have stereospecific effects .
Synthesis of PA-824: It is used in the synthesis of PA-824, a promising antituberculosis drug candidate .
Industrial Chemical Intermediate: Beyond its pharmaceutical applications, (R)-3-chloro-1,2-propanediol is also used as an intermediate in the production of other industrial chemicals .
Research and Development: It is utilized in research and development for the creation of new compounds and materials, particularly in the field of organic chemistry .
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Molecular Formula | C3H7ClO2 |
Molar Mass | 110.539 |
Density | 1.303g/cm3 |
Melting Point | -40°C |
Boling Point | 213°C at 760 mmHg |
Flash Point | 113.3°C |
Water Solubility | soluble |
Vapor Presure | 0.0374mmHg at 25°C |
pKa | 13.28±0.20(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
Refractive Index | 1.473 |
Physical and Chemical Properties | Chemical properties colorless to light yellow liquid, stored in a closed container at room temperature. Boiling point 213 c. |
Use | For the synthesis of Chiral reagents and pharmaceutical intermediates |
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