Promethazine Hydrochloride is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion sickness and has antiemetic and anticholinergic properties (via its action on the dopamine receptor D2). In some countries it is prescribed for insomnia when are contraindicated. It is available in many countries under many brand names. Promethazine was developed in the mid 1940s when a team of scientists from Rhône-Poulenc laboratories were able to synthesize it from phenothiazine and a diamine side chain of diphenhydramine.
Promethazine hydrochloride is a phenothiazine used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures. Promethazine injection is usually given when a person cannot take the medication orally (by mouth). Promethazine hydrochloride is available ingeneric form.
1.Promethazine hydrochlorine for a variety of allergies (such as asthma, urticaria, etc.), vomiting during pregnancy, vertigo caused by boating.
2.Promethazine hydrochlorine can be used in combination with aminophylline for the treatment of asthma.
3.Promethazine hydrochlorine other dubbed hibernation injection for artificial hibernation.
1.Promethazine hydrochlorine for a variety of allergies (such as asthma, urticaria, etc.), vomiting during pregnancy, vertigo caused by boating.
2.Promethazine hydrochlorine can be used in combination with aminophylline for the treatment of asthma.
3.Promethazine hydrochlorine other dubbed hibernation injection for artificial hibernation.
4. Promethazine HCL is used for mucocutaneous allergy: applicable to long-term, seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria, angioneurotic edema, blood or plasma products, allergic reactions, skin scratch disease.
5. Promethazine HCL is used motion sickness: motion sickness prevention, seasickness, halo plane.
6. Promethazine HCL is used for anesthesia and surgery before and after adjuvant therapy, including sedation, hypnosis, analgesia, antiemetic.
7. Promethazine HCL is used For the prevention and treatment of radiation sickness or drug-induced nausea and vomiting.finished medicine drug pharmaceutical.
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Analysi | Specifications | Result |
Assay | ≥98% | 99.2% |
Appearance | White powder | Complies |
Loss on Drying | ≤1.0% | 0.04% |
Ash | ≤1.0% | 0.1% |
As | ≤2.0ppm | <2.0ppm |
Pb | ≤2.0ppm | <2.0ppm |
Insoluble impurity content | ≤0.05% | Complies |
Total Plate Count | ≤1000 cfu/g | Complies |
Yeast &. Mold | ≤100 cfu/g | Complies |
E.Coli | Negative | Negative |
Salmonella | Negative | Negative |
Conclusion |
Conform USP Standard.
|
Promethazine hydrochloride occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is soluble in water and freely soluble in alcohol.
Application:
1. Mucocutaneous allergy: applicable to long-term, seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria, angioneurotic edema, blood or plasma products, allergic reactions, skin scratch disease.
2. Motion sickness: motion sickness prevention, seasickness, halo plane.
3. For anesthesia and surgery before and after adjuvant therapy, including sedation, hypnosis, analgesia, antiemetic.
4. For the prevention and treatment of radiation sickness or drug-induced nausea and vomiting.finished medicine drug pharmaceutical.
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