Nefiracetam

Nefiracetam is a nootropic of the racetam family. Nefiracetam is cognitive enhancer with an IC50 of approximately 150-200 μM for Ro 5-4864. This compound activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Nefiracetam displays potent neuroprotective action in the retinal ischemia-reperfusion modeProduct Display

1. It's a kind of nutritional supplement.

2. It can improve the aerobic metabolism of the muscle and greatly enhance muscle strength and endurance from diet alone.

3. It can be used as nutrition enhancer.

4. It's one of the most popular and effective nutritional supplements as well as the indispensable product for bodybuilders.

5. It is also widely used by other athletes, such as football players, basketball players and so on.

1. Memory. One of the primary Nefiracetam benefits is better memory and information retention in the long term.

2. Learning Ability. There have been studies showing that this supplement can lead to improvements in spatial learning abilities. Nefiracetam also has a much more potent effect on increasing attention spans, concentration and focus as compared to other nootropics like Pramiracetam, Oxiracetam or Piracetam.

3. Healthy Brain Cells. It may also be helpful in treating patients with cognitive decline as well as improving the health and maintenance of your brain cells. Taking Nefiracetam is thought to actually protect brain neurons from premature cell death due to cytoprotective actions.

4. Stress, Anxiety, Depression. Nefiracetam has been found useful for reducing stress, anxiety, and even depression. The mechanisms of action for these supplements are similar in many respects, but Nefiracetam seems to exhibit a wider range of effects.

5. Seizures. Studies also indicate that this supplement might be effective in treating seizures. This includes both convulsive and non-convulsive seizures. The primary effect is to greatly reduce the effects of amygdala based seizures and use for stroke patients in reducing the number and duration of post-stroke seizures.

6. Alzheimer's and Dementia. May have a therapeutic role in Alzheimer's and Dementia, but this has not been well investigated. Preliminary evidence seems promising

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Nefiracetam belong to the non-marginal Enrichment class of drugs, these drugs have different chemical structures, both through the role of the cerebral cortex to enhance cognitive ability and prevent learning and memory damage. It does not have muscarinic receptor agonist and antagonist properties, does not inhibit the activity of Ach, the drug's anti-amnesic and memory-enhancing effect by increasing the release of cerebral cortex Ach achieved.

The memory mechanisms of nefiracetam seem to be linked back to two pathways. One is prolonging the opening of calcium channels which enhances signalling of a receptor independent of the synapse, and the other pathway seems to be tied into PKC and CAMKII which then augments signalling through cholinergic receptors. The former pathway appears to be critical for long-term potentiation, whereas the latter pathway appears to be vital for neuronal signal enhancement.
Some other minor pathways include being a partial agonist at the glycine binding site of the NDMA receptor (may enhance signalling when there are subpar levels of glycine, but attenuates excessive signalling) and increasing affinity of the muscarinic acetylcholine receptors for its ligand, acetylcholine.

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