Levamisole HCl

Levamisole hydrochloride, an organic compound with the chemical formula C11H13ClN2S, is a white to almost white crystalline powder, which is a kind of insect repellent and biological reaction mediator.

This product is white or white acicular crystal or crystalline powder, odorless.
This product is easily soluble in water, easily soluble in ethanol, slightly soluble in trichloromethane, and very slightly soluble in acetone.

It has good curative effect on roundworm, hookworm, pinworm and strongyloidiasis. Because of the high effective rate of single dose, this product is suitable for group therapy. The activity against Filaria Banneri, Filaria malaya and Onchocerca adults and microfilaria was higher than that of ethamizine, but the long-term effect was poor.

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Pharmacology and toxicology:
This product is the left-hand body of tetraimidazole, which can selectively inhibit the succinic dehydrogenase in the muscle of the insect body, so that fumaric acid can not be reduced to succinic acid, thus affecting the anaerobic metabolism of the muscle of the insect body and reducing energy production. When the insect body is in contact with it, it can depolarize the neuromuscle and cause paralysis due to continuous muscle contraction. The cholinoid effect of the drug is beneficial to the excretion of the worm body. Its activity is about 1~2 times that of tetraimidazole (racemic), and the toxic side effects are lower. The drug may inhibit the microtubule structure of the worm. Levamisole also has immunomodulatory and immunomodulatory functions.

Pharmacokinetics:
The peak blood concentration (500mg/mL) was reached within 2 hours after taking 6 tablets, and t1/2 was 4 hours. Metabolized in the liver, this product and its metabolites can be excreted in urine (mostly), feces and respiratory tract, and can also be measured in milk.