Icaridin/Picaridin CAS 119515-38-7 Raw Material

Scientists have developed more and more varieties of penicillin and cephalosporin antibiotics, but it takes at least 15 to 20 years for each new drug to be successfully developed and used on a large scale after the market. Therefore, in order to combat the growing resistance and desensitization challenges of existing drugs, scientists in addition to the development of a new generation of more sensitive drug varieties, another way to solve the problem is to develop a combination containing synergists. Then this research and development than the development of a full sense of new drugs, it can be said that the difficulty of research and development is greatly reduced.
Therefore, for penicillin and cephalosporin drugs, to solve the problem of resistance to these two antibiotics, is to develop and apply B lactamase inhibitors, as well as compound preparations with penicillin and cephalosporin antibiotics, compatible with B lactamides. The difficulty of this research and development is more difficult than completely developing a new drug that has never been developed, and the difficulty of that is not a point or two.
The mechanism of action of such penicillins and cephalosporins is usually as follows: first, Beta lactamase inhibitors have almost no inherent antibacterial effect; Instead, it can inhibit the activity of multiple plasma-mediated Beta lactamases, including ESBLS°. The representative drugs of this class of antibiotic synergists are :① oxypenicillanes: clavulanic acid (potassium); ② Penicillane sulfones: sulbactam, tazobactam, avibactam and other drugs.
These different kinds and varieties of penicillin and cephalosporin antibiotic synergists, in ① inhibitory intensity: Tazobactam > clavulanate > sulbactam; ② Averbactam is a reversible inhibitor of beta-lactamase, and other drugs are irreversible inhibitors of beta-lactamase. These compound preparations containing synergists mainly include ① compound amoxicillin clavulanate potassium powder.
Indications: Oral administration is suitable for various infections caused by drug-resistant bacteria that produce beta-lactamase; For example, salmonella, chicken omphalitis, chicken paste anal, poultry Escherichia coli, egg poultry salpingitis and other diseases. In practical use, it is better to combine ampramycin sulfate "or colistin sulfate, and carbapyrine calcium and other antipyretic analgesics." In addition, amoxicillin can also be combined with sulbactam sodium, and the synergistic effect of this compound is also relatively significant.
In addition to the compound application of amoxicillin clavulanate potassium powder, there are compound amoxicillin and sulbactam sodium application and ② ampicillin sodium "and sulbactam sodium compound; ③ Cefoperazone sulbactam, ④ piperacillin tazobactam, ⑤ ceftazobactam avibactam: active against most carbapenase producing bacteria. 6 Piperacillin sulbactam, 7 ticacillin clavulanic acid and other penicillin and cephalosporin antibiotics, beta-lactam synergist application cases.