Tacrolimus

Tacrolimus, also known as FK506, a fermentation product isolated from Streptomyces, is a macrolide antibiotic and a powerful new immunosuppressant, which mainly inhibits the release of interleukin-2 (IL-2) and comprehensively inhibits the action of T lymphocytes, which is 100 times stronger than cyclosporin (CsA). In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries such as Japan and the United States. Clinical experiments have shown that it has good efficacy in heart, lung, intestine, bone marrow transplantation. At the same time, FK506 also plays a positive role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.

Melting point: 113-115℃
Boiling point: 871.7℃
Flash point: 481.0℃
Density: 1.19g/cm3
Appearance: White or off-white crystalline powder
Refractive index: 1.549

At the molecular level, tacrolimus apparently acts by binding to a cellular protein (FKBP12), which accumulates in the cell to produce its effect. The FKBP12-Tacrolimus complex specifically binds to and inhibits calcineulin, which inhibits calcium-dependent message pathways produced in T cells, thereby preventing the transcription of discontinuous lymphokine genes. This drug is highly immunosuppressive, and its activity has been confirmed in vitro and in vivo. The drug inhibits the production of cytotoxic lymphocytes that are responsible for major graft rejection. It inhibits the activation of T cells and the proliferation of T helper cells dependent on B cells. It also inhibits the production of lymphatic factors such as interleukin-2, interleukin-3, and gamma-interferon, and the expression of interleukin-2 receptors. At the molecular level, the effect of the drug appears to be caused by binding to a cellular protein (FKBP), which also causes the compound to accumulate between cells. In vivo, the drug has been shown to be effective in liver and kidney transplantation.

Nou gen anpil faktori-wo kalite ak gwo koperasyon, ki ka ba ou bon jan kalite pwodwi ak pri konpetitif. Epi nou ka bay tou rabè pou acha esansyèl. Epi nou kolabore ak anpil konpayi transpò machandiz pwofesyonèl, ka delivre pwodwi san danje epi san pwoblèm nan men ou. Tan livrezon se sou 3-20 jou apre konfimasyon peman an.

1. Èske ou se yon faktori oswa yon konpayi komès?
Nou se yon konpayi entegre endistri ak komès, bay yon sèl-stop service.OEM ta ka aksepte.

2. ou bay echantiyon yo genyen? Èske li gratis oswa siplemantè?
Echantiyon gratis. Frè machandiz echantiyon an bezwen peye bò kote ou.

3. Èske ou gen nenpòt sètifika ki gen rapò ak kontwòl kalite?
ISO 9001:2008 sètifikasyon asire bon jan kalite.

4. Kisa mwen ta dwe bay pou jwenn yon sitasyon?
Pls enfòme nou sou kalite pwodwi ou bezwen, kantite lòd, adrès ak kondisyon espesifik yo.Y ap fè sitasyon an pou referans ou nan tan.

5. Ki kalite metòd peman ou pito? Ki kalite kondisyon yo aksepte?
Kondisyon livrezon yo aksepte: FOB, CFR, CIF, EXW;
Aksepte Peman Lajan:USD;
Kalite Peman Aksepte: T/T, Western Union; Paypal, asirans komès.
Lang pale: Angle.