Dehydroepiandrosterone

dehydroepiandrosterone (dehydroepiandrosterone, referred to as DHEA), the chemical name is 3-β-hydroxy-androstane-5-ene-17-ketone, also known as dehydroepiandrosterone, is a kind of cholesterol retention △ 5,6 double bonds and esterification 3-β-hydroxy-steroid, its molecular formula is C19H28O2. Its molecular weight is 288.41, its melting point is 151℃ ~ 153℃, and its rotation is +5.5°. It is a precursor of adrenal hormone secreted by the reticulum layer of the adrenal cortex. It has physiological activities such as regulating obesity, preventing diabetes, anti-carcinogenic and viral infection, improving memory, immune response and stress response, and reducing tension. And involved in the synthesis of adrenal secretion of various hormones.

1. Prevention and treatment of obesity DHEA has a thyroid-like effect, which can inhibit food and fat intake and reduce fat accumulation. Oral small dose of DHEA sulfate can improve the quantity and distribution of body fat and reduce blood lipid. In addition, DS can act on mitochondrial respiratory apparatus, inhibit food and fat intake, and is related to DHEA against glucocorticoids, which can prevent and control obesity.
2. Anti-diabetic DHEA has the effects of improving glucose tolerance, increasing insulin level and anti-diabetes.
3. Anti-cortical diseases DHEA can enhance the activity of the endocrine system, reduce cortisol levels, and play a role in resisting various pathological processes. The symptoms of patients with systemic lupus erythematosus (SLE) improved greatly after taking DHEA, indicating that DHEA has a certain effect on the treatment of SLE. DHEA can help the human body to obtain cortical antibodies. The concentration of DHEA in plasma has a great relationship with various cortical diseases. The lower the concentration, the greater the risk of disease.
4. Anti-cancer DHEA has a certain effect on the prevention and inhibition of tumor growth. Firstly, the anti-carcinogenic effect of DHEA has been clinically found to be related to the reversal of breast cancer. Low levels of DHEA were associated with bladder and stomach cancer and were not associated with age. It has been proven that DHEA has a protective and synergistic effect when used to chemotherapy tumors, because DHEA has an inhibitory effect on 5 phosphoribose, and DHEA plays a role in inhibiting cancer by inhibiting excessive mitochondrial (NADPH) and 5-phosphoribose ester. DHEA can inhibit the growth of pancreatic cancer cells. It is speculated that the mechanism is that DHEA can inhibit the growth of pancreatic cancer cells by regulating the alternating change of plasma estrogen concentration.

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