Artemisinin

 Artemisinin, has been for over two millennia, one of the most common herbs prescribed in traditional Chinese medicine (TCM)(1).

  Artemisinin acts in a multi-specific manner also against hematological malignancies. The chemical structure of Artemisinin is a sesquiterpene lactone, which contains an endoperoxide bridge essential for activity. The main mechanism of action of Artemisinin and its derivatives(artesunate, dihydroartemisinin, artemether) toward leukemia, multiple myeloma, and lymphoma cells comprises oxidative stress response, inhibition of proliferation, induction of various types of cell death as apoptosis, autophagy, ferroptosis, inhibition of angiogenesis, and signal transducers, as NF-κB, MYC, amongst others.

  Many in vivo experiments in disease-relevant animal models demonstrate therapeutic efficacy of artemisinin-type drugs against rheumatic diseases (rheumatoid arthritis, osteoarthritis, lupus erythematosus, arthrosis, and gout), lung diseases (asthma, acute lung injury, and pulmonary fibrosis), neurological diseases (autoimmune encephalitis, Alzheimer's disease, and myasthenia gravis), skin diseases (dermatitis, rosacea, and psoriasis), inflammatory bowel disease, and other inflammatory and autoimmune diseases.

1) Vinpocetine is chemically related to, and derived from vincamine, an alkaloid found in the periwinkle plant.
2) It was introduced into clinical practice in Europe more than two decades ago for its role in cerebrovascular
disorders and related symptoms.
3) Experiments with this periwinkle extract indicate that it can dilate blood vessels, cross the blood-brain
barrier, enhance circulation in the brain, improve oxygen utilization, make red blood cells more pliable, and
inhibit aggregation of platelets.
4) Vinpocetine even has antioxidant properties. Levels peak in the bloodstream within an hour and a half
after ingestion.

1.Artemisia apiaceais used as an antimalarial drug. The clinical application proves that artemisinin and its derivatives have special effects on malaria and falciparum malaria, especially Artemtherin, which is more effective than other artemisinin drugs.

2. Applicable to a variety of malaria, such as falciparum malaria, vivax malaria, anti-chloroquine malaria, and cerebral malaria.

3. The treatment of discoid lupus has a total effective rate of 90%.

4. The treatment of dengue fever is significantly better than Western medicine.

5. Immunologists also found that artemisinin can significantly increase the lymphocyte transformation rate and enhance the immune function of antibodies.

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Artemisinin (qinghaosu) is an antimalarial compound first isolated in pure form in 1972 by Chinese scientists from the herb qinghao (Artemisia annua). This herb (worm wood) has been used in Chinese traditional medicine to control fever for over 2000 years . Artemisinin is a compound with a peculiar structure, low toxicity and high efficacy even in severe chloroquine resistant P. falciparum malaria. Unlike current antimalarial drugs which have a nitrogen-containing heterocylic ring system, it is a sesquiterpene lactone with an endoperoxide linkage. The endoperoxide linkage is essential for the antimalarial activity of the drug. Artemisinin has been shown to be a potent schizontocidal drug both in vitro and in experimental animal models, but it has no practical effect against the exoerythrocytic tissue phase, the sporozoites and the gametocytes.

Primjena
1.Treatment of chronic hepatitis;

2.Treatment of tuberculosis breathing disorder;

3.Treatment of chronic bronchitis;

4.Treatment of acute dysentery;

5.Treatment of vivax malaria;

6.Dermatitis Treatment Oncosphere

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