Udenafil CAS 268203-93-6

Udenafil is the fourth in a class of drugs targeting the inhibition of the enzyme phosphodiesterase 5 (PDE5) for the treatment of erectile dysfunction. Inhibition of PDE5 results in the increase in endogenous cyclic guanosine monophosphate (cGMP) concentrations in the penile corpus cavernosum. cGMP induces smooth muscle cell relaxation and subsequent increased blood flow leading to a sustainable erection. Udenafil is a potent antagonist of human PDE5 with an IC₅₀ of 8.25nM and a comparable selectivity profile as sildenafil for the other PDEs. Unlike tadalafil, it does not inhibit PDE11, which has been implicated in myalgia and testicular toxicity. Furthermore, udenafil produced up to a 91% vaginal penetration success rate and up to a 67% intercourse completion rate compared to a 29% completion rate by placebo. Overall patient satisfaction, measured by a standard global assessment question, was 86% compared to only 26% in the placebo group. The most frequently recorded adverse events were mild-to-moderate facial flushing and headache.

Udenafil is an inhibitor of phosphodiesterase 5 (PDE5). In vivo, udenafil (1 and 5 mg/kg) increases lung cGMP levels, attenuates the development of compensatory right ventricular hypertrophy, and reduces pulmonary arterial wall thickening in a rat model of monocrotaline-induced pulmonary hypertension. It increases creatine clearance and decreases blood urea nitrogen (BUN) and serum malondialdehyde (MDA) levels in a rat model of renal ischemia-reperfusion injury. Udenafil (0.3 and 10 mg/kg) induces penile erections in conscious rabbits and in rabbits with acute spinal cord injury.

Wy hawwe in protte heechweardige fabriken mei djippe gearwurking, dy't jo produkten fan hege kwaliteit en konkurrearjende prizen kinne leverje. En wy kinne ek jouwe koartingen foar bulk oankeapen.En wy gearwurkje mei in protte profesjonele frachtferfier bedriuwen, kinne leverje produkten feilich en soepel oan jo hannen. Levertiid is sawat 3-20 dagen nei befêstiging fan betelling.

Product Name:	Udenafil
Synonyms:	5-[2-propyloxy-5-(2-(1-Methylpyrrolidin-2-yl)ethylaMinosulphonyl)phenyl]-1-Methyl-3-propyl-6,7-dihydro-1H-pyrazolo(4,3-d)pyriMidin-7-one;5-[2-propyloxy-5-[2-(1-Methyl-2-pyrrolidinyl)ethylaMinosulfonyl]phenyl]-1-Methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyriMidine-7-one;Zydena;Udenafil(DA 8159,Zydena);BenzenesulfonaMide,3-(6,7-dihydro-1-Methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyriMidin-5-yl)-N-[2-(1-Methyl-2-pyrrolidinyl)ethyl]-4-propoxy-;Udenafil, DA 8159;CS-1353;Udenafil, >=98%
CAS:	268203-93-6
MF:	C25H36N6O4S
MW:	516.66
EINECS:	251-228-4
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	268203-93-6.mol

1. Binne jo in fabryk of in hannelsbedriuw?
Wy binne in bedriuw dat yndustry en hannel yntegrearret, en leveret ien-stop service.OEM koe wurde akseptearre.

2. Biede jo samples? Is it fergees of ekstra?
Fergees samples. De frachtfergoeding fan 'e stekproef moat troch jo kant betelle wurde.

3. Hawwe jo sertifikaten yn ferbân mei kwaliteitskontrôle?
ISO 9001: 2008-sertifikaasje om kwaliteit te garandearjen.

4. Wat moat ik leverje om in offerte te krijen?
Pls ynformearje ús oer it produkttype dat jo nedich binne, bestellingskwantiteit, adres en spesifike easken.

5. Hokker soarte fan betelling metoade jo leaver? Hokker soarte betingsten wurde akseptearre?
Akseptearre leveringsbetingsten: FOB, CFR, CIF, EXW;
Akseptearre betellingsfaluta: USD;
Akseptearre betellingstype: T / T, Western Union; Paypal, Trade Assurance.
Sprektaal: Ingelsk.