Coluracetam

Coluracetam, also known as BCI-540 or MKC-231, is a nootropic of the racetam class.

Coluracetam was originally studied in Japan in the mid-1990s for Alzheimer's treatment. These studies showed coluracetam's ability to repair memory and learning in mice with damaged nerve cells. However, none of the research on Alzheimer's has ever been published.

Coluracetam's second round of research, by Brain Cells Inc., on more than 100 people with major depression and anxiety, is reported to have shown benefits for major depressive disorder (MDD). However, these trials were never published either.

• Brain Optimization: Coluracetam is a choline uptake enhancer which boosts the effects of choline in your brain. It increases the production of acetylcholine (ACh) through HACU. Resulting in better learning and memory.
• Neurotransmitters: Coluracetam desensitizes glutamate (AMPA) receptors in your brain.[ii] Which boosts neural signaling by increasing the effectiveness of glutamate. Resulting in better focus and concentration.
• Mood & Anti-anxiety: Coluracetam is effective in treating anxiety and depression. Even in people suffering from major depression and who do not respond to SSRI's.

1) Memory and Learning

Coluracetam improved memory and learning in rats treated with a nerve toxin that damages the choline uptake system in the brain. This improvement surprisingly lasted beyond treatment. However, these benefits in learning and memory were not seen in rats who were not exposed to the nerve toxin.

Acetylcholine levels are often lower in those with Alzheimer's. By boosting acetylcholine in the hippocampus, coluracetam may improve some Alzheimer's symptoms, such as poor memory and learning.

In rats that were given the recreational drug (which inhibits ChAT, the enzyme that creates acetylcholine), coluracetam repaired the damage to the learning function by increasing ChAT.

2) Anxiet

In a rat study, dosing 21 days of coluracetam led to a 20% improvement in anxiety, which was greater than the 12% effect had in a single dose in the same study.

3) Schizophrenia

The enzyme that helps make acetylcholine (ChAT) is impaired in schizophrenia.

Coluracetam increased the activity of ChAT in rats with nerve cell damage. More research directly on people with schizophrenia is needed.

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What is this product?

Coluracetam just might be the next new nootropic to dominate the market of brain supplements in the coming years. Like many of the other most popular nootropics, Coluracetam is a Racetam compound derived from Piracetam. Coluracetam has a lot of characteristics in common with other Racetams, but there are also some important distinctions.

Application

1. Used as an intellectual stimulant. It can be used to treat memory and intellectual impairment caused by Alzheimer's disease, mild to moderate vascular dementia, trauma and other conditions, as well as to promote intellectual development in children.
2. Antidepressant effect. By promoting the transmission of nerve signals, it has a significant effect on depression

Formulations/Preparations:Tablets;Injection