Minoxidil

Minoxidil, whose chemical name is 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide, is an organic substance that is white or off-white crystalline powder. Clinically, as a potassium channel opener, it can directly relax vascular smooth muscle, and has a powerful small arterial expansion effect, which reduces peripheral resistance and blood pressure without affecting the volume of blood vessels, so it can promote venous return. At the same time, due to reflex regulation and positive frequency effects, cardiac output and heart rate can be increased, but it does not cause orthostatic hypotension.

(A)Minoxidil Powder can stimulate the proliferation and differentiation of hair follicle epithelial cells: the normal human hair follicle epithelial cells in different concentrations of minoxidil solution in the micro-molar concentration of minoxidil can stimulate hair follicle epithelial cell proliferation.

(B)Minoxidil Powder can promote angiogenesis: increase the local blood supply: hair growth depends on the hair nipple blood supply network nutrition, hair in the different growth cycle, vascular endothelial growth mRNA expression is different from the growth of vascular endothelial growth mRNA in the dermis Nipple cells were strongly expressed, but were less expressed during retrograde and resting periods.

(C)Minoxidil Powde can open potassium channels: potassium channel opening is an important step in regulating hair growth, animal models in vitro and in vivo experiments have shown that minoxidil is a potassium channel activator, can increase the permeability of potassium ions to prevent calcium ion flow Intracellular, resulting in decreased free calcium concentration in cells, while calcium ions, epidermal growth inhibit hair growth.

Minoxidil can be used for refractory hypertension and renal hypertension, the antihypertensive effects of hydralazine stronger than that. Mechanism for the K + channel opening, so that vascular smooth muscle. it Is a vasodilator antihypertensive drug classes. Does not cause orthostatic hypotension, no long-term efficacy of medication.Minoxidil was the first drug approved b for the treatment of androgenetic alopecia (hair loss).Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat high blood pressure that included hair growth and reversal of male baldness.

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Chì ghjè stu pruduttu?

Minoxidil, whose chemical name is 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide, is an organic substance that is white or off-white crystalline powder. Clinically, as a potassium channel opener, it can directly relax vascular smooth muscle, and has a powerful small arterial expansion effect, which reduces peripheral resistance and blood pressure without affecting the volume of blood vessels, so it can promote venous return. At the same time, due to reflex regulation and positive frequency effects, cardiac output and heart rate can be increased, but it does not cause orthostatic hypotension.

Applicazione

Minoxidil is topically applied to the scalp to stimulate hair growth and slow down the progression of hair loss. It is widely used as an over-the-counter treatment for individuals experiencing thinning hair or pattern baldness. Minoxidil is typically available in solutions or foams that are applied directly to the scalp, and it is important for users to follow the recommended application instructions.