Vancomycin is a branched tricyclic glycosylated nonribosomal peptide produced by the Actinobacteria species Amycolatopsis orientalis (formerly designated Nocardia orientalis).Vancomycin exhibits atropisomerism - it has multiple chemically distinct rotamers owing to the rotational restriction of some of the bonds. The form present in the drug is the thermodynamically more stable conformer, so has more potent activity.

Vancomycin is an antibiotic used to treat a number of bacterial infections.It is recommended intravenously as a first-line treatment for complicated skin infections,bloodstream infections, endocarditis, bone and joint infections, and meningitis caused bymethicillin-resistants. aureus. Blood levels may be measured to determine the correct dose.Vancomycin is also recommended by mouth as a treatment for severe Clostridium difficilecolitis. When taken by mouth it is very poorly absorbed.

1. 1.Destroy bacteria by inhibiting their growth and reproduction. This drug interferes with the synthesis of bacterial cell walls by interfering with peptidoglycan, a key component in the cell wall structure, inhibiting the production of phospholipids and polypeptides in the cell wall.

2, Vancomycin is mainly used in four aspects of infection treatment: first, the treatment of drug-resistant bacteria infection; It is also used in the treatment of antibiotic-resistant pseudomembranous enteritis caused by Clostridium difficile.

3, Vancomycin can also be used to treat colitis and intestinal inflammation; Vancomycin is also often used to prevent infection when installing cardiac catheters, intravenous catheters, and other devices. Vancomycin can be taken alone or in combination.

4, can inhibit the synthesis of bacterial cell wall, Staphylococcus aureus, streptococcus pyogenes, streptococcus pneumoniae and other strong effect, on the difficult to distinguish Bacillus, Bacillus anthracis, diphtheria and other good effect.

5, no cross-resistance with other antibiotics, very few drug-resistant strains. It is mainly used in endocarditis, septicemia, pseudomembranous enteritis and so on.

6, the drug is not absorbed by oral administration, and must be dissolved with water for injection before dropping, and the infusion time shall not be less than 1 hour. Too fast droplet can cause skin reaction, and too high concentration can cause thrombophlebitis. Intramuscular injection can cause severe pain, so not intramuscular injection; It has severe ototoxicity and nephrotoxicity, so it should only be used for short-term rescue.

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CERTIFICATE OF ANALYSIS

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Vancomycin is a glycopeptide antibiotic used to treat bacterial infections.Vancomycin is a branched tricyclic glycosylated nonribosomal peptide produced by the Actinobacteria species Amycolatopsis orientalis (formerly designated Nocardia orientalis).

Aplikasyon

This product is limited to systemic infections caused by methicillin resistant Staphylococcus aureus (MRSA) and intestinal infections and systemic infections caused by Clostridium difficile; Patients with penicillin allergy can not use penicillin or cephalosporins, or patients with severe staphylococcal infection who have failed to be treated by the above antibiotics can choose norvancomycin. This product is also used for the treatment of enterococcal endocarditis and corynebacterium (diphtherioid) endocarditis in people allergic to penicillin. Treatment of arteriovenous shunt infection caused by staphylococcus in hemodialysis patients with and without penicillin allergy.